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M9460225.TXT
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1994-06-12
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Document 0225
DOCN M9460225
TI Serologic response to standard inactivated influenza vaccine in human
immunodeficiency virus-infected children.
DT 9408
AU Chadwick EG; Chang G; Decker MD; Yogev R; Dimichele D; Edwards KM;
Department of Pediatrics, Northwestern University Medical School,;
Chicago, IL.
SO Pediatr Infect Dis J. 1994 Mar;13(3):206-11. Unique Identifier :
AIDSLINE MED/94232702
AB We compared the serologic response of 46 human immunodeficiency virus
(HIV)-infected children and adolescents and 61 age-matched controls to
standard trivalent inactivated influenza vaccine (A/Taiwan (H1N1),
A/Shanghai (H3N2), B/Yamagata). Children were immunized according to the
package insert recommendations before the 1990 to 1991 influenza season.
Serum antibody titers to influenza A were determined before and 1 month
after each vaccination and compared for study and control subjects.
Serologic responses of HIV-infected participants were correlated with
absolute CD4 counts and stage of HIV disease. Regardless of age or HIV
status, all groups responded with significant increases in antibody to
the influenza A strains (range, 2.1-fold to 11.8-fold), with the
exception that antibody to H3N2 rose only 1.5-fold (P = 0.058) among
HIV-positive subjects > or = 9 years old. Pre- and postimmunization
antibody titers were significantly higher for controls than for
HIV-positive subjects. There was no correlation between serologic
responses and CD4 counts among HIV-infected subjects, but those with
Centers for Disease Control and Prevention-defined acquired
immunodeficiency syndrome responded significantly less well to vaccine.
We conclude that HIV-infected children and adolescents produce
significant antibody rises after inactivated influenza A vaccination but
that their absolute antibody concentrations are lower than those seen in
age-matched controls.
DE Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Adolescence Antibodies,
Viral/*BIOSYNTHESIS/IMMUNOLOGY Child, Preschool Comparative Study
Female Human Infant Influenza Vaccine/*IMMUNOLOGY Male
Orthomyxoviridae Infections/*PREVENTION & CONTROL Orthomyxovirus Type
A, Human/*IMMUNOLOGY Risk Factors Support, U.S. Gov't, P.H.S.
Vaccination Vaccines, Inactivated/IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).